PAIN AND INFLAMMATION
What is pain and inflammation >
Pain is a general term that describes uncomfortable sensations in the body. It stems from activation of the nervous system. Everyone experiences pain differently due to their different pain tolerance level; some people feel pain that range from annoying to debilitating, some may feel like a sharp stab or dull ache. Pain may also be described as throbbing, pinching, stinging, burning, or sore. Pain can be described as a signaling tool that informs us that something is wrong and hints to us on what is the cause, making it easier for you and healthcare professionals to make accurate and proper diagnosis.
There are several types of pain:
• Acute Pain - Develops over a short period of time
• Chronic Pain - Last, or comes and goes, over multiple months of years
• Nociceptive Pain - Caused by tissue damage
• Functional Pain - Caused by damage to the nerve
Inflammation is a process by which your body's white blood cells and the things your immune system produces that protect you from infection caused by bacteria and viruses. Inflammation can be acute (short-lived) or chronic (long-lasting), which depends on the cause of the inflammation.
Sometimes, inflammation is not caused by infection from outside invaders. It can also be caused by autoimmune diseases. An autoimmune disease is a condition in which your immune system acts as if regular tissues are infected or somehow unusual. This causes your immune system to mistakenly attacks your body, thus triggering inflammation. One example of an autoimmune disease is arthritis.
The scientific cause to pain >
Pain and inflammation is caused by a complex cascading reaction. This cascade of effects include an increase of:
• COX-1 & COX-2 enzyme activity
• 5-LOX enzyme activity
• Oxidative stress
• Reactive Oxygen Species (ROS)
• Free Radical Production
• Messenger compounds, including prostaglandins
Enzymatic pathways in the initiation and progression of the inflammatory response
Information about conventional drugs for pain and inflammation >
Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used drugs for the treatment of pain and inflammation. There are two main types of NSAIDs, non-selective & selective NSAIDs (also called COX-2 inhibitors). They have been associated with serious adverse effects on the gastrointestinal (GI), kidney and cardiovascular (CV) systems.
Some important information on NSAIDs:
1) NSAID medicines may increase the chance of a heart attack or stroke that can lead to death.
This chance increases:
a. With longer use of NSAID medicines
b. In people who have heart disease
2) NSAID medicines can cause ulcers and bleeding in the stomach and intestines at any time during treatment.
Ulcers and bleeding:
a. Can happen without warning symptoms
b. May cause death
3) NSAID medicines should be avoided if patients have chronic kidney disease.
4) NSAID medicines should never be used right before or after heart surgery, where the surgery is also known as
"coronary artery bypass graft (CABG)".
5) Talk to your healthcare provider before using over-the-counter NSAIDs for more than 10 days.
Shima Michael et al. European Journal of Pharmaceutical and Medical Research 2017; 4(6): 268-270
Innovative Ingredient - UNIVESTIN™
A natural Anti-Inflammatory Product for Pain and Inflammation >
UNIVESTIN™ is a proprietary patented blend of Scutellaria baicalensis and Acacia catechu, from Unigen®, USA.
How does UNIVESTIN™ work >
UNIVESTIN™ works by modulating all 3 enzymatic pathways involved in inflammation (COX-1, COX-2 and LOX). This natural supplement assists to put an end to joint and muscular pain. This naturally derived product also helps to reduce the symptoms of arthritis such as pain and stiffness, as well as increase mobility.
UNIVESTIN™ has undergone extensive preclinical and clinical testing to confirm the encouraging results of this naturally derived ingredients that help to reduce the pain and inflammation.
Clinically tested >
UNIVESTIN™ helps to provide relief of pain and inflammation associated with arthritis, including osteoarthritis and rheumatoid arthritis. UNIVESTIN™ has an excellent tolerability profile with minimal side effects.
GRAS (Generally Recognized as Safe), USFDA:
• UNIVESTIN™ have been designated as GRAS according to strict USFDA standards, the highest standard of safety.
The ingredients that have been safely consumed by widespread populations around the world.
• Over 4 billion doses of 250mg UNIVESTIN™ prescribed with no known side effects.
• UNIVESTIN™ helps to maintain healthy cardiovascular, gastrointestinal and kidney functions.
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This is for educational purposes only. Kindly consult healthcare professionals for further information.
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