IRRITABLE BOWEL SYNDROME
What is Irritable Bowel Syndrome (IBS) >
Irritable Bowel Syndrome is not a disease. It's a functional disorder, which means that the bowel simply does not work as it should.
(IBS) is a common disorder that affects the large intestine (colon).
(IBS) commonly causes cramping, abdominal pain, bloating, gas, diarrhea and constipation.
Is IBS common? >
• Prevalence 3 - 22% world-wide
• Reason for 20 - 50% of gastroenterology visits
• 26% prevalence among children with recurrent abdominal pain
• 40% onset before age 35
• 50% onset age 35 – 50
The Human Colon >
Colon is the part of the large intestine, the last portion of the human gastrointestinal tract. It provides 3 main functions::
• The organ for storing waste products by elimination of toxic waste material in the form of stool
• Reabsorbing water from wastes and maintaining water balance in the body
• Serves at the site for the growth of beneficial bacteria and other microorganisms
The contraction of the colon muscles and the movement of its contents is controlled by nerves, hormones, and impulses in the colon muscles. These contractions move the contents inside the colon toward the rectum. During this passage, water and nutrients are absorbed into the body, and what is left over is stool.
However, if the muscles of the colon do not contract in the right way, the contents inside the colon do not move correctly. Resulting in abdominal pain, cramps, constipation, a sense of incomplete stool movement, or diarrhea (IBS Symptoms)!
Causes of IBS >
• Abnormal gastrointestinal (GI) tract movements
• Dysbiosis due to antibiotic treatment
• A change in the nervous system communication between the GI and brain
• Sensory and motor disorders of the colon
• Dietary allergies or food sensitivities
• Neurotransmitter imbalance (decreased serotonin levels)
• Severe lack of fiber intake
• Old age
• Alcohol or smoking
Pain, distension or abdominal discomfort and bloating
Abnormal bowel habits with periods of constipation
and / or diarrhea
Sensation of incomplete bowel movement
Mucus in the stool
What is Butyrate >
Butyrate is produced when the human gut microbiota, mainly butyrogenic bacteria ferments dietary non-digestible carbohydrates (fiber such as whole vegetables and fruits, beans and lentils, whole wheat, and other grains). Butyrate is one of the end products called short chain fatty acid, SCFA of this fermentation process. Where butyrate is used as a treatment for IBS.
How Sodium Butyrate Works As IBS treatment >
Provides energy for the colonocytes
• 70% of energy used by the colon is from butyrate
• Relieves constipation
Increase mucus production
• Provides good environment for good bacteria to grow
• Keeps pathogens and bad bacteria from causing damage
Anti-pathogenic and antimicrobial activities
• Prevents growth of bad bacteria and pathogens that harm the intestine
Regulation of immune processes through anti-inflammatory effects
• Decrease inflammation, less abdominal pain
Maintaining proper intestinal smooth muscle tone and sensitivity of visceral sensory receptors
• Less incidence of diarrhea occurrence
Regulation of apoptosis and cell division
• Ensures the intestine is in healthy and rejuvenated state
Increase epithelial permeability (intestinal barrier)
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