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What is Irritable Bowel Syndrome (IBS) >

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    Irritable Bowel Syndrome is not a disease. It's a functional disorder, which means that the bowel simply does not work      as it should.

    (IBS) is a common disorder that affects the large intestine (colon).

    (IBS) commonly causes cramping, abdominal pain, bloating, gas, diarrhea and constipation.

Is IBS common? >

Prevalence 3 - 22% world-wide

Reason for 20 - 50% of gastroenterology visits

26% prevalence among children with recurrent abdominal pain

 40% onset before age 35

 50% onset age 35 – 50

The Human Colon >


Colon is the part of the large intestine, the last portion of the human gastrointestinal tract. It provides 3 main functions::

The organ for storing waste products by elimination of toxic waste material in the form of stool

Reabsorbing water from wastes and maintaining water balance in the body

Serves at the site for the growth of beneficial bacteria and other microorganisms

Human colon peristalsis diagram.jpg

The contraction of the colon muscles and the movement of its contents is controlled by nerves, hormones, and impulses in the colon muscles. These contractions move the contents inside the colon toward the rectum. During this passage, water and nutrients are absorbed into the body, and what is left over is stool.

However, if the muscles of the colon do not contract in the right way, the contents inside the colon do not move correctly. Resulting in abdominal pain, cramps, constipation, a sense of incomplete stool movement, or diarrhea (IBS Symptoms)!

Causes of IBS >

Abnormal gastrointestinal (GI) tract movements

Dysbiosis due to antibiotic treatment

A change in the nervous system communication between the GI and brain

 Sensory and motor disorders of the colon

Dietary allergies or food sensitivities

Neurotransmitter imbalance (decreased serotonin levels)

Severe lack of fiber intake


 Old age


Alcohol or smoking


Symptoms >

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Pain, distension or abdominal discomfort and bloating

Abnormal bowel habits with periods of constipation

and / or diarrhea

Sensation of incomplete bowel movement

Mucus in the stool

Butyrate Graph.jpg

What is Butyrate >

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Butyrate is produced when the human gut microbiota, mainly butyrogenic bacteria ferments dietary non-digestible carbohydrates (fiber such as whole vegetables and fruits, beans and lentils, whole wheat, and other grains). Butyrate is one of the end products called short chain fatty acid, SCFA of this fermentation process. Where butyrate is used as a treatment for IBS.

How Sodium Butyrate Works As IBS treatment >

Provides energy for the colonocytes

70% of energy used by the colon is from butyrate

Relieves constipation

Increase mucus production

​​ Provides good environment for good bacteria to grow

Keeps pathogens and bad bacteria from causing damage

Anti-pathogenic and antimicrobial activities

​​ Prevents growth of bad bacteria and pathogens that harm the intestine

Regulation of immune processes through anti-inflammatory effects

​​ Decrease inflammation, less abdominal pain

Maintaining proper intestinal smooth muscle tone and sensitivity of visceral sensory receptors

​​ Less incidence of diarrhea occurrence

Regulation of apoptosis and cell division

​​ Ensures the intestine is in healthy and rejuvenated state

Increase epithelial permeability (intestinal barrier)

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